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Glutathione steps in during Phase II, known as the conjugation phase, to neutralize these highly reactive intermediates before they can cause systemic tissue damage

et al., 2020), indicating that elevated arachidonic acid metabolism promoted the occurrence of liver ferroptosis in mice, with the accumulation of lipid peroxides, an increase in mitochondrial reactive oxygen species, and changes in mitochondrial morphology

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Survival data showed that patients with grades IIIV and grades IIIIV had an increased risk of death (HR 1.64 and 2.83)